Pneumococcal infection represents a wide range of diseases caused by the bacterium Streptococcus pneumoniae (or more commonly referred as pneumococcus). While pneumococcus is a common cause of mild illnesses such as sinus or middle ear infections, it may also cause severe or even life-threatening invasive pneumococcal diseases (IPD) such as bacteremic pneumonia, sepsis, and meningitis. The outcomes for IPD are usually more severe among young children and elderly persons.
Pneumococcal vaccination is one of the most effective means of preventing pneumococcal diseases.
What is the difference between 23-valent pneumococcal polysaccharide vaccine (23vPPV) and 13-valent pneumococcal conjugate vaccines (PCV13)?
PCV13 is effective against both invasive pneumococcal disease and non-invasive pneumococcal pneumonia. On the other hand, while clinical studies indicated that 23vPPV is generally effective in preventing IPD, its efficacy against non-invasive pneumococcal pneumonia is suboptimal. Nevertheless, it is worth noting that 23vPPV contains more serotypes and theoretically offers extra protection.
If elderly have received 13-valent pneumococcal conjugate vaccine (PCV13) before, do they need revaccination of pneumococcal vaccine?
For elderly aged 65 years or above, who have previously received one dose of PCV13 before, if they do not have risk factors for IPD, no further pneumococcal vaccination is needed. If they have risk factors for IPD, they should receive one dose of 23vPPV one year after the previous PCV13 administration.
If elderly have received 23-valent pneumococcal polysaccharide vaccine (23vPPV) before, do they need revaccination of pneumococcal vaccine?
For elderly who have previously received 23vPPV before, if they do not have risk factors for IPD, no further pneumococcal vaccination is needed. If they have risk factors for IPD, they should receive one dose of PCV13 one year after the previous 23vPPV.
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